8-pCPT-cGMP, TEA Lyophilized. HYGROSCOPIC. Selective membrane-permeable activator of protein kinase G that has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg. Purity: ≥98% by HPLC. Ref.: Alioua, A., et al. 1998. J. Biol. Chem. 273, 32950. Draijer, R., et al. 1995. Circ. Res. 77, 895. Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031. Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734. |
