Sp-8-Br-PET-cGMPS, Na Lyophilized. HYGROSCOPIC. A potent, selective, cell-permeable activator of PKG type Ia (Ka = 2.5 µM) and Ib (Ka = 2.6 µM). Also acts as a blocker of retinal type of cGMP-gated ion channels (IC50 = 105 µM). Does not affect the activity of PKA II (Ka > 1000 µM). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases and shows no metabolic side effects. More lipophilic and cell-permeable than Sp-8-pGMPS. Note: 5 µmol = 2.81 mg. Purity: ≥98% by HPLC. CAS 172806-21-2. Ref.: Wei, J.Y., et al. 1996. Biochemistry 35, 16815. Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI. |
