2-(4-(2-(1-Cyclohexanebutyl-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic Acid
GW647 White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable urea-substituted thioisobutyric acid (ureido-TiBA) compound that acts as a potent and selective PPARa agonist (PPARa, g and d - EC50 = 6 nM, 1.1 µM and 6.2 µM for human; 1 nM, 1.3 µM and 2.9 µM for murine, respectively). Also displays in vivo lipid-lowering activity in rats. Purity: ≥98% by HPLC. CAS 265129-71-3. Ref.: Muoio, D.M., et al. 2002. J. Biol. Chem. 277, 26089. Brown, P.J., et al. 2001. Bioorg. Med. Chem. Lett. 11, 1225. Oliver, W.R. Jr., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 5306. Poirier, H., et al. 2001. Biochem. J. 355, 481. |
