2-Chloro-5-nitro-N-phenylbenzamide

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, selective and irreversible PPARg antagonist (IC₅₀ = 3.3 nM, 32 nM, and 2 µM for PPARg, PPARa, and PPARd, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXR_a), retinoic acid receptor (RAR), retinoid X receptor-a (RXR_a) and thyroid receptors a and b (TR_a and TR_b). Purity: ≥95% by HPLC. CAS 22978-25-2.

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