1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl Light yellow lyophilized solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A broad-based, cell-permeable serine/threonine kinase inhibitor. Inhibits protein kinase A (Ki = 3.0 µM), myosin light chain kinase (Ki = 97 µM), protein kinase C (Ki = 6.0 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells. Purity: ≥98% by TLC. CAS 108930-17-2. Ref.: Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730. Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707. Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334. Gimond, C., et al. 1992. Exp. Cell Res. 203, 365. Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657. Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198. Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218. Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542. Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258. |
