N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl Lyophilized. A potent, cell-permeable inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM). Purity: >95% by TLC. CAS 113276-94-1. Ref.: Ido, M., et al. 1991. Br. J. Cancer 64, 1103. Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523. Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577. Hidaka, H., et al. 1984. Biochemistry 23, 5036. |
