Isoapoptolidin, Nocardiopsis sp. White lyophilized solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. A cell-permeable ring-expanded macrolide isomer of Apoptolidin (Cat. No. 178495) with over 20-fold less inhibitory activity against F0F1-ATPase (IC50 = 17 µM in yeast). Isoapoptolidin quickly isomerizes to and co-exists with Apoptolidin in equilibrium (k1 = 0.0626 h-1 and Keq = 0.638 in Dulbecco's PBS at 37°C). Purity: ≥90% by HPLC. CAS 476647-30-0. Ref.: Wender, P.A., et al. 2002. Chem. Lett. 4, 3819. |