N-(2-Aminoethyl)-5-isoquinolinesulfonamide, 2HCl Lyophilized. Closely resembles H-8 in chemical structure and inhibitory potency. Cell-permeable inhibitor of protein kinase A (Ki = 1.9 µM), protein kinase C (Ki = 18 µM), and protein kinase G (Ki = 870 nM). Useful as a ligand for separation and purification of these enzymes. Purity: >97% by TLC. CAS 84468-17-7. Ref.: Hirayama, T., et al. 1990. Microb. Pathog. 8, 421. Inagaki, M., et al. 1985. J. Biol. Chem. 260, 2922. |
