N-Formyl-3,4-methylenedioxy-benzylidine-g-butyrolactam
KNK437

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK. Purity: ≥95% by HPLC.

Ref.: Koishi, M., et al. 2001. Clin. Cancer Res. 7, 215. Yokota, S., et al. 2000. Cancer Res. 60, 2942.
R: 20/21/22; S: 36