HEP, Na White solid. Anticoagulant. Inhibits the IP3-activated Ca2+ channel release of the endoplasmic reticulum. Reported to activate the ryanodine receptor. Totally prevents adenophostin-induced release of Ca2+ from cerebellar and intracellular stores. Note: 1 KU = 1000 units. Activity: ≥140 USP units/mg dry weight. RTECS MI0850000, CAS 9041-08-1. Merck Index: 14, 4653 Ref.: Seuwen, K., and Boddeke, H.G. 1995. Br. J. Pharmacol. 114, 1613. Ehrlich, B.E., et al. 1994. Trends Pharmacol. Sci. 15,145. Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369. R: 22; S: 36 |