Yellow solid. PROTECT FROM LIGHT. A potent and cell-permeable protein tyrosine kinase inhibitor. Inhibits p60v-src (IC50 = 12 µM) and PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Reported to inhibit c-Src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane. Also shown to inhibit anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Purity: ≥95% by HPLC. RTECS LX8930000, CAS 70563-58-5. Ref.: Fan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57. Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061. Migita, K., et al. 1994. J. Immunol. 153, 3457. Okabe, M., et al. 1994. Leuk. Res. 18, 867. Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661. Obinata, A., et al. 1991. Exp. Cell Res. 193, 36. Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237. Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148. Oikawa, T., et al. 1989. Cancer Lett. 48, 157. Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803. Uehara, Y., et al. 1988. Virology 164, 294. Omura, S., et al. 1979. J. Antibiotics 32, 255. |
