C6 Ceramide White waxy solid. Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells. Purity: ≥98% by TLC. CAS 124753-97-5. Ref.: Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047. Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040. Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523. Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572. Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
R: 36/37/38; S: 26-36 |
