4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide M344 White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells. Purity: ≥98% by HPLC. Ref.: Ramiszewski, S.W., et al. 2002. J. Med. Chem. 45, 753. Jung, M., et al. 1999. J. Med. Chem. 42, 4669. |