trans-5-[m-Hydroxyphenyl]-2-n-butyl-1,3-dioxo-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-b-carboline Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable tryptophan-based hydantoin compound that acts as a potent blocker of cell-division by targeting the motor function of the mitotic kinesin Eg5 (IC50 = 800 nM). Purity: ≥97% by HPLC. Ref.: Marcus A.I., et al. 2005. J. Biol. Chem. 280, 11569. Hotha, S., et al. 2003. Angew. Chem. Int. Ed. 42, 2379.
Sold under license of U.S. Patent 6,890,933. |
