Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A thioether compound that inhibits collagen-specific Hsp47-induced collagen chaperone activity in an in vitro fibril formation assay (IC50 = 6.3 µM in phosphate buffer pH 7.4 at 34°C, 800 nM collagen, and 1.2 µM Hsp47). Purity: ≥98% by HPLC (sum of two isomers). Ref.: Thomson, C.A., et al. 2005. J. Med. Chem. 48, 1680. |
