KKKALNRQLGVAA MAPKAP Kinase-2 Inhibitor MK2 Inhibitor White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. A 13-residue peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase [also called mitogen-activated protein kinase-activated protein kinase-2 (MAPKAP kinase-2)]. Inhibition is competitive with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). Purity: ≥98% by HPLC. H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH Ref.: Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239. |