Liquid. In 100 mM NaCl, 50 mM Tris-HCl, 1 mM DTT, pH 7.5. AVOID FREEZE/THAW CYCLES. Native, human Hsp90. A ~90 kDa heat shock protein that is constitutively expressed and resides in the cytoplasm. It exists as a dimer and binds to other cellular proteins such as p60v-src, steroid receptors, heme-regulated protein kinase, actin, and tubulin. Binds to histones with high affinity and induces chromatin condensation. Purity: ≥90% by SDS-PAGE. Ref.: Kim, H.R., et al. 1999. J. Biochem. 126, 1025. Schnaider, T., et al. 1999. Life Sci. 65, 2417. Welch, W.J., et al. 1982. J. Biol. Chem. 257, 14949. |
