1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl
HA1100 Liquid. A 10 mM (2 mg/582 µl) solution in H2O. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKb, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo. Purity: ≥98% by HPLC. CAS 155558-32-0. Ref.: Ito, K., et al. 2003. J. Physiol. 546, 823. Takemoto, M., et al. 2002. Circulation 106, 57. Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029. |
