HNE
4-Hydroxy-2-nonenal Liquid. Supplied at 10 mg/ml in ethanol A major aldehyde product formed by peroxidation of w-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK). Purity: ≥98% by HPLC. RTECS RA8510000, CAS 75899-68-2. Ref.: Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535. Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772. Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135. Siems, W.G., et al. 1996. Free Radic. Res. 20, 215. Ullrich, O., et al. 1996. Free Radic. Res. 24, 421. van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420. Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
R: 11; S: 7-16 |
