Hydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester
Pro-drug II Colorless oil. A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC50 = 100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM). Purity: ≥98% by TLC. Ref.: Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885. Saperstein, R., et al. 1989. Biochemistry 28, 5694. | 
