IL-1b Converting Enzyme (ICE) Inhibitor I
L-709049
Ac-YVAD-CHO White solid. A potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells. Purity: ≥95% by TLC. Ac-Tyr-Val-Ala-Asp-CHO Ref.: Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Los, M., et al. 1995. Nature 375, 81. Walker, N.P.C., et al. 1994. Cell 78, 343. Wilson, K.P., et al. 1994. Nature 370, 270. Thornberry, N.A., et al. 1992. Nature 356, 768. |
