IL-1b Converting Enzyme (ICE) Inhibitor II
Ac-YVAD-CMK White solid. Supplied as a trifluoroacetate salt. PROTECT FROM MOISTURE. A cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. Purity: ≥95% by HPLC. CAS 178603-78-6. Ac-Tyr-Val-Ala-Asp-CMK Ref.: Brenner, B., et al. 1998. Cell Death Differ. 5, 29. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Enari, M., et al. 1995. Nature 375, 78. Walker, N.P.C., et al. 1994. Cell 78, 343. Thornberry, N., et al. 1992. Nature 356, 768. |
