Z-Asp-[(2,6-dichlorobenzoyl)oxy]methane
Z-D-CH2-DCB
ICE Inhibitor V Colorless amorphous solid. PROTECT FROM MOISTURE. A potent inhibitor of caspase-1-like proteases. Blocks apoptotic cell death in human myeloid leukemia U937 cells and blocks etoposide-induced DNA fragmentation. Purity: ≥95% by HPLC. Z-Asp-CH2-DCB Ref.: Kawaguchi, M., et al. 1999. Gan To Kagaku Ryoho. 26, 679. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Mashima, T., et al. 1995. Biochem. Biophys. Res. Commun. 209, 907. Dolle, R.E., et al. 1994. J. Med. Chem. 37, 563. |
