White solid. Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents. Purity: >98% by elemental analysis. RTECS YT4900000, CAS 127-07-1. Merck Index: 14, 4848
Ref.: Leyden, D., et al. 2000. Anticancer Res. 20, 133. Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347. Anand, S., et al. 1995. Cancer Lett. 88, 101.
R: 46-61; S: 45-53 |
