Black solid. PROTECT FROM LIGHT. Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 mM). Also known to inhibit casein kinase II (IC50 = 6 nM), MAP kinase (IC50 = 4 nM), and the protein tyrosine activities of the insulin receptor (IC50 = 20 - 29 nM) and the epidermal growth factor receptor (IC50 = 35 nM). Purity: ≥95% by HPLC. CAS 548-04-9. Merck Index: 14, 4863
Ref.: Zhang, W., et al. 1997. Cancer Lett. 120, 31. Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615. Frew, T., et al. 1994. Anticancer Res. 14, 2425. Barnard, D.L., et al. 1992. Antiviral Res. 17, 63. Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.
R: 22; S: 22-36 |
