3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester
Hypoxia-Inducible Factor-1 Inhibitor Light beige powder. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1a protein, while exhibiting no apparent effect on the cellular level of HIF-1a mRNA or that of HIF-1b protein. Purity: ≥95% by HPLC. Ref.: Lee, K., et al. 2007. J. Med. Chem. 50, 1675. | 
