3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one
SU5607

Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent and selective inhibitor of casein kinase (CK1) that inhibits CK1d (IC₅₀ = 0.7-1.3 µM) and CK1e (IC₅₀ = 0.6-1.4 µM) isozymes. Also inhibits CK1a₁ at much higher concentrations (IC₅₀ = 11-21 µM). The inhibition is competitive with respect to ATP. Only weakly inhibits PKA, p34^cdc2, and p55^fyn (IC₅₀s > 100 µM). At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest. Purity: ≥95% by HPLC (sum of two isomers). CAS 186611-52-9.

Ref.: Behrend, L., et al. 2000. Oncogene 19, 5303. Mashhoon, N., et al. 2000. J. Biol. Chem. 275, 20052. Knippschild, U., et al. 1997. Oncogene 15, 1727.