3-[(Decahydro-1b,2b,4ab-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone IQ Red solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1. Purity: ≥98% by HPLC. CAS 71678-03-0. Ref.: Radeke, H.S., et al. 1999. Chem. Biol. 6, 639. Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227. Jamora, C., et al. 1997. Cell 91, 617. Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671. Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323. Takizawa, P.A., et al. 1993. Cell 73, 1079. Veit, B., et al. 1993. J. Cell Biol. 122, 1197. |