7-Methoxy-5,11,12-trihydroxy-coumestan
Wedelolactone, Eclipta alba Yellowish green solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. The naturally isolated active ingredient of the herbal medicine, Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKa and b kinase activity (IC50 < 10 µM). Inhibits NF-kB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IkBa. Has no effects on p38 MAP kinase or Akt. Purity: ≥95% by HPLC. CAS 65646-68-6. Ref.: Kobori, M., et al. 2004. Cell Death Differ. 11, 123. Li, C.C., et al. 2003. J. Org. Chem. 68, 8500. Mors, W.B., et al. 1989. Toxicon 27, 1003. Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374. |
