Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IkBa degradation and NF-kB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Purity: ≥97% by HPLC. Ref.: Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108. |
