Dark red solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent inhibitor of GSK-3b (glycogen synthase kinase 3b), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC50 = 22 nM, 180 nM, and 100 nM, respectively). Inhibits the proliferation of a large range of cells by arresting them in the G2/M phase of the cell cycle. Inhibits Tau phosphorylation in vitro and in vivo at Alzheimer’s disease-specific sites. Also reported to inhibit the in vivo phosphorylation of DARPP-32 by Cdk5 on Thr75. Purity: ≥ 98% by HPLC. CAS 160807-49-8. Ref.: Bain, J., et al. 2003. Biochem. J. 371, 199. Leclerc, S., et al. 2000. J. Biol. Chem. 276, 251. Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60. |
