Dark red solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A highly potent inhibitor of glycogen synthase kinase-3b (GSK-3b; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes. Purity: ≥97% by HPLC. Ref.: Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251. Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60. |
