1-(p-Chlorobenzoyl)-2-methoxy-3-methyl-1H-indole-3-acetic Acid White to off-white powder. A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Ab-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells. Purity: ≥98% by assay. RTECS NL3500000, CAS 53-86-1. Merck Index: 14, 4968
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