D-Ins(1,3,4,5)P₄, 8K

Solid. PROTECT FROM MOISTURE. HYGROSCOPIC. PACKAGED UNDER INERT GAS. Formed by phosphorylation of Ins(1,4,5)P₃. Suggested to play a second-messenger role different from that of Ins(1,4,5)P₃. A weak agonist of Ca²⁺ mobilizing receptors that is reported to mobilize intracellular Ca²⁺ stores in saponin-permeabilized SH-SY5Y neuroblastoma cells (EC₅₀ = 2.05 µM). Purity: ≥98% by NMR. CAS 135269-51-1.

Ref.: Wilcox, R.A., et al. 1993. Mol. Pharmacol. 44, 810. DeLisle, S. 1992. Am. J. Physiol. 262, C1456. Irvine, R.F. 1992. FASEB J. 6, 3085. Balla, T., et al. 1991. J. Biol. Chem. 266, 24719.