3-F-Ins(1,4,5)P3, 6Na White crystalline solid. HYGROSCOPIC. Equipotent to Ins(1,4,5)P3 in releasing intracellular calcium. The 3-position is blocked by fluorine, hence it cannot be converted to Ins(1,3,4,5)P4 by the action of 3-kinases. May be a useful tool for studying the complex biochemical pathways in which InsP3 and InsP4 are closely interactive. CAS 129365-68-0. Ref.: Rubinstein, E., et al. 1992. Blood 79, 2901. Kozikowski, A.P., et al. 1990. J. Am. Chem. Soc. 112, 7403. Bartha, K., et al. 1989. Biochem. J. 263, 149. |
