BB-loop Mimic
Hydrocinnamoyl-L-valyl Pyrrolidine
TIR Domain Mimic

Colorless oil. PACKAGED UNDER INERT GAS. A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1b-induced fever in mice in vivo and to attenuate IL-1b-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro. Purity: ≥95% by HPLC.

Ref.: Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.