rhIL-2 Lyophilized. Carrier-free Recombinant, human interleukin-2 expressed in E. coli. Has a variety of immunological functions. IL-2 is secreted by activated T cells. Acts as an autocrine agent to promote proliferation and maturation of activated T cells. Human IL-2 is active in murine cell lines. Exhibits about 60% amino acid homology with murine IL-2. Inhibits dexamethasone-induced apoptosis in T lymphocytes. Induces nitric oxide synthase. Biological activity: ED50 = 80-500 pg/ml as measured in a cell proliferation assay with an IL-2-dependent murine cytotoxic T cell line. Purity: ≥95% by SDS-PAGE. Contaminants: Endotoxin: ≤100 pg/µg IL-2. RTECS NM9742000. Merck Index: 14, 4994
Ref.: Migliorati, G., et al. 1994. Pharmacol. Res. 30, 43. Nakamura, Y., et al. 1994. Cancer Res. 54, 5757. Karanth, S., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3383. Maeda, A., et al. 1983. Biochem. Biophys. Res. Commun. 115, 1040. Taniguchi, T., et al. 1983. Nature 302, 305. |
