5-Iodo-6-amino-1,2-benzopyrone Yellow to gold solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable poly(ADP-ribose) polymerase (PARP) inhibitor. Offers protection against peroxynitrite and hydroxyl radicals in vitro and in vivo and abrogates peroxynitrite-induced mitochondrial transmembrane potential (DYm) reduction. Also exhibits malignant phenotype reversal in cancer cells and inhibits HIV-1 IIIb replication in vitro. Purity: ≥98% by HPLC. CAS 137881-27-7. Ref.: Szabó, C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3867. Szabó, C. 1998. Shock 9, 341. Virag, L., et al. 1998. J. Immunol. 161, 3753. Bauer, P.I., et al. 1995. Biochimie 77, 374. Cole, G.A., et al. 1991. Biochem. Biophys. Res. Commun. 180, 504. |
