4-Amino-5-iodo-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine
ITU Tan solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent and competitive inhibitor of the MAP kinase ERK2 (Ki = 530 nM). Also inhibits adenosine kinase (Ki = 30 nM), serine/threonine kinases such as casein kinase I and PKA, and the insulin receptor kinase fragment (IC50 values range from 0.4-28 µM). Purity: ≥90% by HPLC. CAS 24386-93-4. Ref.: Fox, T., et al. 1998. Protein Science 7, 2249. Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397. Massillon, D., et al. 1994. Biochem. J. 299, 123. Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424. Newby, A.C., et al. 1993. Biochem. J. 214, 317. |
