IBMX White solid. A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-a expression in adipocyte precursor cells. Purity: ≥98% by TLC. RTECS ZD8500000, CAS 28822-58-4. Ref.: Hube, F., et al. 1999. Horm. Metab. Res. 31, 359. Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373. Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119. Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876. Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95. Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150. Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451. |
