1,5-Dihydroxyisoquinoline
5-Hydroxy-1(2H)-isoquinoline
1,5-Isoquinolinediol White to off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC50 = 390 nM). Blocks nitric oxide-induced neuronal toxicity. Purity: ≥98% by TLC. CAS 5154-02-9. Ref.: Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305. Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14. Zhang, J., et al. 1994. Science 263, 687. Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569. |
