N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide
Inhibitor of Trichostatin A 1

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable benzotriazole amide that counteracts and complements histone and tubulin deacetylase (HDAC and TDAC) inhibitors. Inhibits tubulin acetylation mediated by Trichostatin A, but not by Taxol. Through its successful use with TSA in vivo, it was shown that the expression of Rhodopsin-GFP transgene in Zebrafish eye is regulated via a mechanism involving reversible histone acetylation. Purity: ≥95% by HPLC. CAS 200626-61-5.

Ref.: Haggarty, S.J., et al. 2003. Chem. Biol. 10, 383. Koeller, K.M., et al. 2003. Chem. Biol. 10, 397.