4-(4′-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
WHI-P131 White to off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation. Purity: ≥97% by HPLC. Ref.: Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815. Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569. Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742. Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
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