4-[(3′-Bromo-4′-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline
WHI-P154 Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration. Purity: ≥97% by HPLC. CAS 211555-04-3. Ref.: Ghosh, S., et al. 2001. Acta Crystallogr. C. 57, 76. Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569. Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742. Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.
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