4-(3′,5′-Dibromo-4-hydroxyphenyl)amino-6,7-dimethoxyquinazoline
WHI-P97 Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent cell-permeable and specific inhibitor of JAK3 (IC50 = 11 µM). Inhibits JAK3 in immune complex kinase assays in a dose-dependent fashion and reduces the invasiveness of EGFR positive human cancer cells in a dose-dependent manner. Purity: ≥92% by HPLC. CAS 211555-05-4. Ref.: Ghosh, S., et al. 1999. Anticancer Res. 14, 403. Sudbeck, E.A., et al. 1999 Clin. Cancer Res. 5, 1569.
Sold under license of U.S. Patent 6,080,748 and corresponding patents. |
