Off-white to light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Purity: ≥95% by HPLC. CAS 102396-24-7. Ref.: Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527. Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259. Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46. Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869. Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
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