Anthra[1,9-cd]pyrazol-6(2H)-one
1,9-pyrazoloanthrone
SAPK Inhibitor II
SP600125 Yellowish orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-g, TNF-a, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. Purity: ≥98% by HPLC. RTECS CB4585000, CAS 129-56-6. Ref.: Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311. Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681. Han, Z., et al. 2001. J. Clin. Invest. 108, 73. |
