2-Naphthyl-(N-isopropyl,N-benzyl)-b-aminoethylketone, HCI
ZM 39923 White crystalline solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A (b-aminoethyl)ketone that acts as a potent and selective ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3; pIC50 = 7.1). A weak inhibitor of other tyrosine kinases (pIC50 = 5.6 for EGF-R; 4.4 for JAK1). It undergoes a retro-Michael breakdown (t1/2 = 36 min at 25°C, pH 7.43) to another active 2-naphthylvinyl ketone analog (JAK Inhibitor V; Cat. No. 420122) [pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1]. Purity: ≥99% by HPLC. CAS 58753-54-1. Ref.: Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.
Sold under license of PCT Application W098/22,103. |
