Yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable 3′-pyridyl oxindole compound that acts as a potent inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005). Purity: ≥98% by HPLC. CAS 856436-16-3. Ref.: Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press. Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105. |
