1,2,3,4,5,6-Hexabromocyclohexane Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in g2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts. Purity: ≥ 99% by titration. CAS 1837-91-8. Ref.: Sandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526. |
